Fred MacMurray as Agent Dick Grant, alias Richard Hood

Madge Evans as Helen Sherwood

David Holt as David Sherwood

Lynne Overman as Agent Gabby Lambert

John Wray as Gangster Sam "Red" Hammond

Leslie Fenton as Monk Gleason, gang boss

Elizabeth Patterson as Ella Ferris

Grant Mitchell as Andrew Webster, banker

Harry Tyler as Lanky Gangster (script name: Steve)

Clyde Dilson as Butch, beefy gangster

George Lloyd as Louie, beefier and dull-witted gangster

Arthur Aylesworth as Area Agent Drew

Helen Shipman as Becky Ferris

Herbert Rawlinson as Chief Agent Crawford

Dean Jagger as Agent Jones

J. C. Nugent as Major Newcomb, publisher

Hilda Vaughn as Miss Simpson, gang "nurse"

Paul Fix as Cowardly Gangster in Getaway Launch

Frank Sheridan as Kansas City Police Commissioner

Phil Tead as Talkative Reporter

Sam Godfrey as Wiseguy Reporter

Jack Mulhall as Quiet Reporter

Russ Clark as Agent Adams

Frank Shannon as Agent Joe

Irving Bacon as Old-Timer on Bench

A.S. Byron as Post Office Goofball

Ben Taggart as Kansas City Police Chief

Creighton Hale as Groom

Oliver Eckhardt as Usher at Wedding

Buddy Roosevelt as FBI Agent

Ivan Miller as FBI Agent

Stanley Andrews as Jim, the Fingerprint Man

Helen Brown as Dorothy Lambert

Ricca Allen as Miss Lucy Withers

Caroline Rankin as Miss Alice Withers

Ben Hall as Mr. Youngblood (uncredited)

Henry Roquemore as Mr. Hines