Michael Keaton as Henry Hackett

Robert Duvall as Bernie White

Glenn Close as Alicia Clark

Marisa Tomei as Martha Hackett

Randy Quaid as Michael McDougal

Jason Alexander as Marion Sandusky

Catherine O'Hara as Susan

Jason Robards as Graham Keighley

Siobhan Fallon Hogan as Lisa

Jill Hennessy as Deanne White

Spalding Gray as Paul Bladden

Lynne Thigpen as Janet

Jack Kehoe as Phil

Roma Maffia as Carmen

Clint Howard as Ray Blaisch

Geoffrey Owens as Lou

Amelia Campbell as Robin

William Prince as Howard Hackett

Augusta Dabney as Sarah Hackett

Bruce Altman as Carl

Jack McGee as Wilder

Bobo Lewis as Anna

Edward Hibbert as Jerry

Michael Countryman as Emmett

Joe Viviani as Max

Julie Rowen as Kathy

Ed Jupp Jr. as Copy Editor

Christi Hatcher as City Editor

Gary Dourdan as Copy Guy

James Ritz as A.C. Repairman

Miles Watson as A.C. Repairman

Divina Cook as Sobbing Woman

Aloysius R. Burke as Parking Cop

Benny Benowitz as Crazy Guy

Lee Kimball as Security Guard

Michael P. Moran as Chuck

Jack O'Connell as Press Operator

Herb Krystall as Pressroom Foreman

Herb Lovelle as Victor

John Eric Bentley as Paste-Up Person

Vincent D'Arbouze as First Kid

Michael Michael as Second Kid

Yvonne Warden as Woman with Dog

Louisa Marie as Sentinel Receptionist

Stephen Koepp as German Newsperson

Victor Truro as Bernie's Doctor

Cedric Young as Martha's Paramedic

Wylie Weeks as Martha's Paramedic

James Colby as Alicia's Paramedic

Paul Geier as Doctor Porter

Rance Howard as Alicia's Doctor

Maureen Goldfedder as Alicia's E.R. Nurse

Karen Church as Alicia's Nurse

Diane Gnagnarelli as Pediatric Nurse

David J. Birnbach as Anesthesiologist

Amos Grunebaum as Obstetrician

Victoria Thomas as E.R. Doctor

Jacqueline Murphy as O.R. Nurse

Jean Speegle Howard as Hospital Volunteer

Joe Pentangelo as Arresting Officer

Jim Meskimen as Tom

Tony Hoty as Waiter

Sally-Jane Heit as Grace

Mike Girard Sheehan as Richie

Herbert Rubens as Tony

Cheryl Howard as Redheaded Barmaid

Carol Ann Donohue as Crying Child

Shannon E. Donohue as Grumpy Child

Jeffrey H. Kaufman as Police Officer

Myra Taylor as Mother

Jan Mickens as Diner Owner

Daniel Kenney as Pinhead

Harsh Nayyar as Attendant

Frank Inzerillo as News Truck Driver

Rosanna Scotto as Rosanna Scotto

Donna Hanover as Donna Hanover

Jane Hanson as Jane Hanson

Valerie Coleman as Valerie Coleman

Chuck Scarborough as Chuck Scarborough

Brenda Blackmon as Brenda Blackmon

Cynthia Carter as Cynthia Carter