Danny DeVito as Lawrence Garfield

Gregory Peck as Andrew Jorgenson

Penelope Ann Miller as Kate Sullivan

Piper Laurie as Bea Sullivan

Dean Jones as Bill Coles

R. D. Call as Arthur

Mo Gaffney as Harriet

Bette Henritze as Emma

Tom Aldredge as Ozzie

Leila Kenzle as Marcia

Cullen O. Johnson as Gus

William De Acutis as Pfeiffer

David Wells as Granger

Stephanie White as Angeli

Jeff Hayenga as Klein

Ric Kidney as Richardson

Wallace G. Lane Jr. as Woody

Steve White as Richard

Brian Evers as Elton

Max Robinson as Ed

Al Cerullo as Helicopter Pilot

Michael Laskin as Concierge

Barney Brown as Kate's Neighbor

Sandy Moore as Samules

Paul Coyne as Security Guard

Dale Kasman as Receptionist

Kathleen Piché as Receptionist

Peter Brocco as Garfield's Office Valet

Nancy Omi as Japanese Waitress

Mark Pinter as Bart

Mary Hedahl as TV Reporter

Leslie Devlin as FNN Reporter

William 'Skip' Church as Reporter #1

Cam McCormack as Camerawoman

Glenn K. Pearson as Reporter #2

Patrick James Grosswendt as Factory Worker

Raul Kobrinsky as Proxy Monitor

Woodrow W. Asai as Japanese Businessman #1

Ken Kensei as Japanese Businessman #2

Shirô Oishi as Japanese Businessman #3

Philip Perlman as Garfield Supporter

Denise Lynne Roberts as Garfield Employee

Janet M. Smith as Lawyer

Kevin Christy Hayes as Lawyer

Richard Arlen Chapman as Lawyer

Dennis J. Malone as Lawyer

Kevin Lord as Account Executive

Marianne Lewis as Executive Secretary

Tessa Gaynor as Secretary