Keith Ferguson as Megamind (voice)

Laura Post as Roxanne Ritchi (voice)

Josh Brener as OI' Chum (voice)

Maya Tuttle as Keiko Morita (voice)

Emily Tuñon as Lady Doppler (voice)

Talon Warburton as Lord Nighty-Knight (voice)

Scott Adsit as Pierre Pressure (voice)

Chris Sullivan as Behemoth (voice)

Tony Hale as Mel / Mr. Donut / TV Announcer (voice)

Adam Lambert as Machiavillain (voice)

Jeanine Mason as Christina Christo / Hostess (voice)

Michael Beattie as Eccentric Eddie (voice)

Eric Fogel as Polly 227 (voice)

Todd Haberkorn as Big King Fish (voice)

Eric Murphy as Blue Mackerel (voice)

Joey Rudman as Red Snapper (voice)

Roger Craig Smith as Mayor (voice)

Carlos Alazraqui as Additional Voices (voice)

Eric Bauza as Additional Voices (voice)

Kimberly Brooks as Additional Voices (voice)