Robin Williams as Dale Putley

Billy Crystal as Jack Lawrence

Julia Louis-Dreyfus as Carrie Lawrence

Nastassja Kinski as Collette Andrews

Charlie Hofheimer as Scott Andrews

Bruce Greenwood as Bob Andrews

Dennis Burkley as Calvin the Trucker

Haylie Johnson as Nikki Trainor

Charles Rocket as Russ Trainor

Patti D'Arbanville as Shirley Trainor

Jared Harris as Lee

Louis Lombardi as Matt

Mark McGrath as Sugar Ray Band

Jason Reitman as Wrong Kid in Alley

Catherine Reitman as Victoria

Dana Gould as Room Service Waiter

Meagen Fay as Megan

Harry Northup as Reno Jail Cop

Paul Herman as Mr. Barmore

J. Anthony Pena as Boat Painter (as Jose Esau Pena)

Craig Bullock as Sugar Ray Band

Charles Stan Frazier as Sugar Ray Band

Matthew Murphy Karges as Sugar Ray Band

Rodney Sheppard as Sugar Ray Band

Alan Berger as Rex

Tom Verica as Peter

Jennifer Crystal Foley as Rose

David Ripley as Roadie #1

Rhino Michaels as Roadie #2

William Hall as Hotel Clerk

Ricky Harris as Bellhop

Chris Jaymes as Gas Station Guy

Claudette Wells as Ms. Tweesbury

Susan Traylor as Flight Attendant

Mary Gillis as Slot Machine Lady

Mindy Seeger as Nurse

Jennifer Echols as Ball Park Vendor

Marc Glimcher as Cashier

Geoffrey Infeld as Mime

Tamara Zook as Francine the Waitress

Frank Medrano as Mechanic

Elston Ridgle as Security Guard

Kim Shattuck as The Muffs

Ronnie Barnett as The Muffs

Roy McDonald as The Muffs

Caroline Reitman as Lost Girl

Lee Weaver as Airline Passenger

Andre Zotoff as Doorman

Khariah Ford as Woman in Lobby

Jasmine Rose as Nosering Girl

Mel Gibson as Scott the Body Piercer (uncredited)

Mary McCormack as Virginia Farrell (uncredited)