John Travolta as James Ubriacco

Kirstie Alley as Mollie Ubriacco

Olympia Dukakis as Rosie

Lysette Anthony as Samantha

David Gallagher as Mikey Ubriacco

Tabitha Lupien as Julie Ubriacco

Danny DeVito as Rocks (voice)

Diane Keaton as Daphne (voice)

George Segal as Albert

Charles Barkley as Himself

John Stocker as Sol

Elizabeth Leslie as Ruthie

Caroline Elliott as Kid at Schoolyard

Vanessa Morley as Kid at Schoolyard

Sandra P. Grant as Accountant

Sheila Paterson as Old Waitress

Amos Hertzman as Pimply Faced Kid

Mark Acheson as Burly Dad

Kyle Fairlie as Kid on Santa's Lap

Victoria Brooks as Bratty Girl

Ron Gabriel as Seedy Santa

Frank C. Turner as Dave

Serge Houde as Maitre D'

Michael Puttonen as Dog Catcher

Roger Cross as Pilot

Michael Ryan as Pilot

Philip Maurice Hayes as Pilot

Miriam Smith as Tipsy Secretary

Robert Wisden as Ranger

J. B. Bivens as Ranger

Tegan Moss as Girl with Puppy

Chilton Crane as Girl's Mommy

Alicia Bradsen as Mollie at 12

Gina Chiarelli as Young Rosie

Ghislaine Crawford as Reindeer Girl

Justine Crawford as Reindeer Girl

Andrew Airlie as Co-Pilot

Andrea Nemeth as Babysitter

Campbell Lane as Mollie's Dad

Bob Bergen as Dog / Wolf (voice)

Peter Iacangelo as Dog / Wolf (voice)

Nick Jameson as Dog / Wolf (voice)

Patricia Parris as Dog / Wolf (voice)

Patrick Pinney as Dog / Wolf (voice)

Rodney Saulsberry as Dog / Wolf (voice)

Jeff Winkless as Dog / Wolf (voice)

Nick Conti as Coach (uncredited)

Brent Sheppard as Ranger (uncredited)