Diane Morgan as Philomena Cunk

Douglas Hedley as Self

Rupert Sheldrake as Self

Alison Wright as Self

Celia Deane-Drummond as Self

Paul Nurse as Self

Jim Al-Khalili as Self

Joyce Harper as Self

Prokar Dasgupta as Self

Anil Seth as Self

Ruth Adams as Self

Joanna Woodall as Self

Gregory Dart as Self

Stephen Case as Self

Ruth Chang as Self

Peter Kail as Self

Richard Thomson as Self

Brian Cox as Self

Michelle Greenidge as Jacqui Flink

Charles Aitken as Waylon Jackalope IV

Genevieve Gaunt as Puppet (voice)

Kat Kumar as Puppet (voice)

Jerry Wilder as Adam

Atlanta Johnson as Eve

Rory Bray as Edwin Hubble

Eleanor Seeley as Mrs Hubble

Greg Lockett as Doll Advert Voice Over (voice)

Charlie Brooker as BBC Announcer (voice) (uncredited)