Will Ferrell as Harold Crick

Maggie Gyllenhaal as Ana Pascal

Dustin Hoffman as Professor Jules Hilbert

Emma Thompson as Karen Eiffel

Queen Latifah as Penny Escher

Tony Hale as Dave

William Dick as IRS Co-Worker #1

Guy Massey as IRS Co-Worker #2

Martha Espinoza as IRS Co-Worker #3

T.J. Jagodowski as IRS Co-Worker #4

Peter Grosz as IRS Co-Worker #5

Tonray Ho as IRS Co-Worker #6

Herb Lichtenstein as IRS Co-Worker #7

Stacey Elaine Jackson as IRS Co-Worker #8

Ricky Adams as Young Boy

Christian Stolte as Young Boy's Father

Denise Hughes as Kronecker Bus Driver

Peggy Roeder as Polish Woman

Danny Rhodes as Bakery Employee #1

Linara Washington as Bakery Employee #2

Helen Young as Bakery Customer #1

David Pompeii as Bakery Customer #2

David Wiegers as Bakery Customer #3

Jarrett Sleeper as Bakery Customer #4

Larry Neumann Jr. as Homeless Man

John Mohrlein as Man with Hose

Tom Hulce as Dr. Cayly

Bruce Jarchow as Commuter

Linda Hunt as Dr. Mittag-Leffler

Kristin Chenoweth as Book Channel Host

Bradley Mott as Large Man on Bus

John M. Watson Sr. as TV Author

Karen Lloyd as Customer with Tan

Keith Kupferer as Demolition Foreman

Danny McCarthy as Demolition Crew #1

Tab Baker as Demolition Crew #2

Mark Buettner as Claw Operator

Christian Young as ER Doctor #1

Ray Kurut as ER Doctor #2

Michael Cook as ER Doctor #3

Arraon Skippa Hixson as Young Man Patient

Bryan Kelly as ER Orderly

Whitney Sneed as ER Nurse #1

Celeste Pechous as ER Nurse #2

Cheryl Lynn Bruce as Head ER Nurse

Chet Dubowski as Man in Tweed

Ora Jones as Banneker Press Receptionist

Jordan Keller as Grocer

Jordan Teplitz as Old Man on Phone

Ricardo Gutierrez as Bus Company Manager

James Mazza as Irritated Man on Bus

Oscar Roxas as Another Man on Bus

Nadirah Bost as Accident Witness

Sandra Marquez as Accident Witness

Lacy Katherine Campbell as Accident Witness

Will Clinger as Accident Witness

Al Samuels as Accident Witness

Frank Caeti as Accident Witness

Andrew Rothenberg as Doctor Mercator

Rengin Altay as Nurse

Lucinda Kemp as Bus Operator #1

Donna Watkins as Bus Operator #2

Julia Heron as Animal Footage Voice Over (voice)

Lora Cain as Animal Footage Voice Over (voice)

Bob Papenbrook as Animal Footage Voice Over (voice)

Mike McColl as Animal Footage Voice Over (voice)

Nathan Adloff as Bakery Patron (uncredited)

Sia A. Moody as Nurse #3 (uncredited)

Eli Goodman as Augustus Chatman (uncredited)

Edy Cullen as Business Women (uncredited)

Tim Krueger as Business Man (uncredited)