Will Ferrell as Brennan Huff

John C. Reilly as Dale Doback

Richard Jenkins as Dr. Robert Doback

Mary Steenburgen as Nancy Huff

Adam Scott as Derek

Kathryn Hahn as Alice

Andrea Savage as Denise

Rob Riggle as Randy

Lurie Poston as Tommy

Elizabeth Yozamp as Tiffany

Logan Manus as Chris Gardoki

Travis T. Flory as Redheaded Kid

Lili Rose McKay as 7-Year-Old Girl

Shira Piven as Nurse

Seth Morris as Doctor

Wayne Federman as Blind Man

Maria Quiban as TV Anchor

Danielle Schneider as Receptionist

Gillian Vigman as Pam Gringe

Brian Huskey as Interviewer

Adam McKay as Man without Glasses

Seth Rogen as Sporting Goods Manager

Chris Henchy as First Homebuyer

Mary Catherine Hamelin as First Homebuyer

Ian Roberts as Male Therapist

Erica Vittina Phillips as Second Homebuyer

Phil LaMarr as Second Homebuyer

Jason Davis as TJ

Paula Killen as Rental Agent

Ken Jeong as Employment Agent

Horatio Sanz as Lead Singer

Kyle Felts as Wine Mixer Heckler

Jake Szymanski as Caterer

Matt Walsh as Drunk Corporate Guy

Dmitri Schuyler-Linch as 6-Year-Old Derek

Bryce Hurless as 9-Year-Old Brennan

Brent White as Therapy Patient

Denise Austin as Herself

John D. Crawford as Bekins Mover