Ricky Gervais as Dr. Bertram Pincus

Greg Kinnear as Frank Herlihy

Téa Leoni as Gwen Herlihy

Billy Campbell as Richard

Aasif Mandvi as Dr. Jahangir Prashar

Dana Ivey as Marjorie Pickthall

Kristen Wiig as Surgeon

Michael-Leon Wooley as Hospital Lawyer

Alan Ruck as Ghost Dad

Jordan Carlos as Young Husband

DeQuina Moore as Young Wife

Joseph Badalucco Jr. as Accident Bystander #1

Brian Hutchison as Accident Bystander #2

Tyree Michael Simpson as Sneezy Cop

Julia K. Murney as Sneezy Lady

Claire Lautier as Upper East Side Lady

Bridget Moloney as Receptionist

Raymond J. Lee as Greenpeace Guy

Joey Mazzarino as Food Delivery Guy

Brad Oscar as Day Doorman

Kathleen Landis as Resident

Audrie Neenan as Admitting Nurse

Aaron Tveit as Anesthesiologist

Deborah S. Craig as Nurse

Betty Gilpin as WWII Nurse

Angelis Alexandris as Elderly Couple

Elaine Kussack as Elderly Couple

Brian Tarantina as Ghost Cop

Darren Pettie as Construction Worker Ghost

Jesse Means as Construction Worker Ghost

Robert Kelly as Construction Worker Ghost

Gabrielle Fink as Violin Student

Monte Bezell as Cab Driver

Sebastian La Cause as Bartender

Miles Grose as Night Doorman

Jeff Hiller as Naked Guy Ghost

Lou Sumrall as Harley Guy Ghost

Raymond McAnally as Assorted Ghost

Amy Van Nostrand as Assorted Ghost

Ira Hawkins as Assorted Ghost

Danai Gurira as Assorted Ghost

Richard O'Rourke as Man at Lecture

Brian d'Arcy James as Irish Eddie

Jazz as Other Leonard

Josh Clayton as Waiter

Lisa Datz as Happy Person in Bar

James Ludwig as Happy Person in Bar

Melissa Thomas as Dr. Prashar's Patient

Shan Hill as Bongo Player

Megan Byrne as Mrs. Pickthall's Daughter

José Ramón Rosario as Crane Operator

Jose Soto as Welder

Candace Thompson as Harley Guy's Old Lady

Dylan Clark Marshall as Little Alex

Alex Eckstein as Mrs. Pickthall's Grandson (uncredited)

Tina King as Nurse (uncredited)

Nicholas Julius as Orderly (uncredited)

John Ahrens as Jogger Ghost (uncredited)

Christina Russo as Elevator Ghost (uncredited)

Marmee Regine Cosico as Ghost (uncredited)

Ezie Cotler as Ghost (uncredited)