Luke Wilson as Henry Poole

George López as Father Salizar

Radha Mitchell as Dawn Stupek

Morgan Lily as Millie Stupek

Adriana Barraza as Esperanza

Cheryl Hines as Meg

Earl Carroll as Mr. Lawrence

Noah Dahl as Young Henry Poole

Rachel Seiferth as Patience

Nick Dash as Security Guard

Andrew Santino as Hospital Orderly

Richard Benjamin as Dr. Fancher

Beth Grant as Josie

Sam Jaeger as Lance

Molly Hagan as Pediatrician

Dan Callahan as Hospital Young Doctor

Gloria Garayua as Female Worshipper

Michelle Krusiec as Young Nurse