Edward Norton as Bill Kincaid / Brady Kincaid

Susan Sarandon as Daisy Kincaid

Richard Dreyfuss as Pug Rothbaum

Keri Russell as Janet

Melanie Lynskey as Colleen

Lucy DeVito as Anne Greenstein

Kent Jude Bernard as Philosophy Student

Amelia Campbell as Maggie Harmon

Tim Blake Nelson as Bolger

Randal Reeder as Shaver

Leo Fabian as Waddell

Pruitt Taylor Vince as Big Joe Sharpe

Tina Parker as Sharon

Ty Burrell as Professor Sorenson

Lee Wilkof as Professor Nathan Levy

Josh Pais as Ken Feinman

Lisa Benavides as Suzie Feinman

Steven E. Williams as Synagogue Parishioner (uncredited)

Maggie Siff as Rabbi Zimmerman

Tim Ware as Minister Davies

Ken Cheeseman as Jimmy Fuller

Steve Earle as Buddy Fuller

Lee Wilkof as Professor Levy

Jim Henry as Policeman (uncredited)