Uma Thurman as Diana

Evan Rachel Wood as Young Diana

Eva Amurri as Maureen

Gabrielle Brennan as Emma McFee

Brett Cullen as Paul McFee

Oscar Isaac as Marcus

Jack Gilpin as Mr. McClood

John Magaro as Michael Patrick

Nathalie Paulding as Amanda (Teen)

Maggie Lacey as Amanda (Adult)

Lynn Cohen as Sister Beatrice

Molly Price as Diana's Mother

Oliver Solomon as Detective

Anna Moore as Blonde Student

Isabel Keating as Maureen's Mother

Adam Chanler-Berat as Ryan

Tanner Cohen as Nate Witt

Sharon Washington as Nurse

Kia Jam as Doctor

J.T. Arbogast as Male Reporter

Jewel Donohue as Mother at Shooting

Tuck Milligan as Clinic Doctor