Helen Hunt as April Epner

Bette Midler as Bernice Graves

Colin Firth as Frank

Matthew Broderick as Ben Green

Ben Shenkman as Dr. Freddy Epner

Lynn Cohen as Trudy Epner

John Benjamin Hickey as Alan

Salman Rushdie as Dr. Masani

Daisy Tahan as Ruby

Tommy Nelson as Jimmy Ray

Stephanie Yankwitt as Stacey

Lillias White as Sheila

David Callegati as Gianni

Kenneth Stern as Rabbi

Robert LuPone as Ted

Chris Chalk as Orderly

Alexa Scott-Flaherty as Mother #2

Marina Durell as Attendant

Sadie Heston as Trudy Jr.

Stephanie Berry as Principal Petticord

Lauren Klein as Alice

Cherise Boothe as Mother #1

Doug Hughes as Bernice Fan

Chelsea Altman as Girl in Freddy's Bed

Stacie Linardos as Anne

Jordan Thaler as Jordan

Michael Harder as Michael

Geneva Carr as Woman in Her 20s

Maryann Urbano as Woman in Her 30s

Maggie Siff as Lily

Janeane Garofalo as Janeane Garofalo

Tim Robbins as Tim Robbins

Edie Falco as Edie Falco