Jennifer Aniston as Nina Borowski

Paul Rudd as George Hanson

Alan Alda as Sidney Miller

Nigel Hawthorne as Rodney Fraser

John Pankow as Vince McBride

Tim Daly as Dr. Robert Joley

Allison Janney as Constance Miller

Steve Zahn as Frank Hanson

Amo Gulinello as Paul James

Bruce Altman as Dr. Goldstein

Kevin Carroll as Louis Crowley

Lauren Pratt as Sally Miller

Kali Rocha as Melissa Marx

Lena Cardwell as Girl at Community Center

Natalie B. Kikkenborg as Girl at Community Center

Hayden Panettiere as Mermaid

Lauren Chen as Violin Player

Liam Aiken as Nathan

Janet Zarish as Dinner Guest

Ellen Tobie as Dinner Guest

Virl Andrick as Dinner Guest

Robert C. Lee as Dinner Guest

Bradley White as Stephen Saint

Marilyn Dobrin as Mrs. Sarni

Midori Nakamura as Nina's Colleague

Joan Copeland as Madame Reynolds

Kate Jennings Grant as Kennedy

Salem Ludwig as Mr. Shapiro

Antonia Rey as Mrs. Ochoa

Danny Darrow as Nina's Dance Partner

Sean Rademaker as School Child

Heather Thompson as School Child

Mary McIlvaine as Nurse

Lisa-Erin Allen as Nurse

Samia Shoaib as Suni

Doug Wert as Father

Shawn Phelan as Son

Edward James Hyland as Doctor

Gabriel Macht as Steve Casillo

John Roland as TV Anchor

Rosanna Scotto as TV Anchor

Miguel Maldonado as Colin Powell

Peter Maloney as Desk Clerk

Bette Henritze as Mrs. Skinner

Iraida Polanco as Carmelita

Sarah Knowlton as Caroline Colucci

Steven Ochoa as Waiter

Kia Goodwin as Juliet

Daniel Cosgrove as Trotter Bull

Damian Young as Romeo & Juliet Director

Rebecca Eichenberger as Wedding Guest

Jane Bodle as Wedding Guest

Audra McDonald as Wedding Singer

Fanni Green as Nurse

Sarah Hyland as Molly

Paz de la Huerta as 13-Year-Old Sally

Jeffrey M. Marchetti as Parent

Susan Bradford as Parent

Ava Lee Scott as Woman in Central Park