Debi Derryberry as Jimmy Neutron (voice)

Jeffrey Garcia as Sheen Estevez (voice)

Rob Paulsen as Carl Wheezer (voice)

Mark DeCarlo as Hugh Neutron (voice)

Carolyn Lawrence as Cindy Vortex (voice)

Frank Welker as Goddard (voice)

Crystal Scales as Libby Fallfax (voice)

Megan Cavanagh as Judy Neutron (voice)

Charlie Adler as Junkman (voice)

Jeff Bennett as Travoltron (voice)

S. Scott Bullock as King Goobot (voice)

Tim Curry as Professor Calamitous(voice)

Paul Greenberg as Brobot (voice)

Maurice LaMarche as Zia (voice)

Wendie Malick as Beautiful Gorgeous (voice)

Andrea Martin as Ms. Fowl (voice)

Edie McClurg as Grandma Taters (voice)

Candi Milo as Nick Dean (voice)

Kevin Michael Richardson as Tee (voice)

Billy West as Sam Melnick (voice)