Rod Taylor as Pongo (voice)

J. Pat O'Malley as Colonel / Jasper (voice)

Betty Lou Gerson as Cruella De Vil / Miss Birdwell (voice)

Martha Wentworth as Nanny / Queenie / Lucy (voice)

Ben Wright as Roger (voice)

Cate Bauer as Perdita (voice)

David Frankham as Sergeant Tibbs (voice)

Frederick Worlock as Horace / Inspector Craven (voice)

Lisa Davis as Anita (voice)

Tom Conway as Quizmaster / Collie (voice)

Tudor Owen as Towser (voice)

George Pelling as Danny (voice)

Ramsay Hill as Television Announcer / Labrador (voice)

Sylvia Marriott as Countess (voice)

Queenie Leonard as Princess (voice)

Marjorie Bennett as Duchess (voice)

Mickey Maga as Patch (voice)

Barbara Beaird as Rolly (voice)

Mimi Gibson as Lucky (voice)

Sandra Abbott as Penny (voice)

Thurl Ravenscroft as Captain (voice)

Bill Lee as Roger (singing voice)

Bob Stevens as Narrator (voice)

Paul Wexler as Car Mechanic (voice)

Mary Wickes as Freckles (voice)

Barbara Luddy as Rover (voice)

Lisa Daniels as Perdita (voice)

Helene Stanley as (voice)

Don Barclay as Truck Driver (voice)

Jeanne Bruns as Radio Singer (voice)

Lucille Bliss as TV Commercial Singer (voice)

Paul Frees as Dirty Dawson (voice)