Uma Thurman as Dr. Emma Lloyd

Jeffrey Dean Morgan as Patrick Sullivan

Colin Firth as Richard Braxton

Sam Shepard as Wilder

Isabella Rossellini as Mrs. Greta Bollenbecker

Keir Dullea as Mr. Carl Bollenbecker

Ajay Naidu as Deep

Sarita Choudhury as Sunny

Jeffrey Tedmori as Ajay

Lindsay Sloane as Marcy

Nick Sandow as Larry

Michael Mosley as Declin

Adesola A. Osakalumi as Didier

Justina Machado as Sofia

Brooke Adams as Carolyn

Lindsey Kraft as Lauren

Yolande Bavan as Naniji

Devika Bhise as Chandini

Santo Fazio as Security Guard #1

Hudson Cooper as Security Guard #2

John Rothman as Business Man

Elisabeth A. Furtado as Gay Partner

Beth Dzuricky as Gay Partner

Tony Rigo as Bartender

Gary Cowling as Clerk

Ilana Levine as Autograph Seeker

Thomas Mintz as Engineer

Welker White as Cake Consultant

Kristina Klebe as Katerina

April Yvette Thompson as Business Woman

Octavio Gómez Berríos as Latino Delivery Guy

Thom Prin Jr. as FDNY Guy

Ben Hauck as Proby

David Scott Klein as Book Party Guest

Irmingard Klebe as Aunt Irmingard

Joerg Klebe as Uncle Joerg

Kaushik Shastry as Pandit

John Rue as Fireman Dispatcher

Nicole Burdette as Woman Caller (voice)

Terrence Quinn as Bar Patron

Christopher Breslin as Bar Patron

Edward Sullivan as Bar Patron

Kelly Ebsary as Fan

Joseph DeBona as Friend in Van

Deep Singh as Singer

Sandhya Jain as Singer

Manprit Bhoday as Singer

Kevin Dhaniram as Singer

Sibtain Rahim as Singer

Raymond Grappone as Singer

Sunny Jain as Singer

Sandra Park as Singer

Kathryne Isabelle Easton as Sushi Waitress

Laura McDavid as Waitress (uncredited)