Uma Thurman as Sissy Hankshaw

Lorraine Bracco as Delores Del Ruby

Pat Morita as The Chink

Angie Dickinson as Miss Adrian

Keanu Reeves as Julian Gitche

John Hurt as The Countess

Rain Phoenix as Bonanza Jellybean

Ed Begley Jr. as Rupert

Carol Kane as Carla

Sean Young as Marie Barth

Crispin Glover as Howard Barth

Roseanne Barr as Madame Zoe

Buck Henry as Dr. Dreyfus

Grace Zabriskie as Mrs. Hankshaw

Treva Jeffryes as Young Sissy

Ken Kesey as Sissy's Daddy

Ken Babbs as Sissy's Uncle

Allen Arnold as Lionel

Victoria Williams as Cowgirl Debbie

Heather Graham as Cowgirl Heather

Judy Robinson as Cowgirl Gloria

Betsy Roth as Cowgirl Mary

Arlene Wewa as Big Red

Heather Hershey as Cowgirl Donna

Dee Fowler as Cowgirl Kym

Udo Kier as Commercial Director

Wade Evans as Cameraman

Tom Peterson as Crewman

Alexa D'Avalon as Rubber Rose Bird Expert

Eric Hull as White House Undersecretary

Oliver Kirk as Sheriff

Joe Ivy as FBI Director

Greg McMickle as FBI Agent

Lin Shaye as Rubber Rose Maid

Chel White as Brain Surgeon

Molly Little as Salsa Singer

Scott Patrick Green as Pilgrim Man

Suzanne Solgot as Pilgrim Woman

Michael Parker as Pilgrim Driver

William S. Burroughs as Self

Sherry Alps as Cowgirl

Eliza Butterfly as Cowgirl

Boo Connolly as Cowgirl

Christie Flenniken as Cowgirl

Stacey Hyder as Cowgirl

Tina Knaggs as Cowgirl

Tom Robbins as Narrator (voice)

Roger Bowen as Naturalist (uncredited)

Edward James Olmos as Musician at Barbecue (uncredited)