Hayden Christensen as Clay Beresford

Jessica Alba as Sam Lockwood

Terrence Howard as Dr. Jack Harper

Lena Olin as Lilith Beresford

Christopher McDonald as Dr. Larry Lupin

Sam Robards as Clayton Beresford Sr.

Arliss Howard as Dr. Jonathan Neyer

Fisher Stevens as Dr. Puttnam

Georgina Chapman as Penny Carver

David Harbour as Dracula

Steven Hinkle as Young Clay

Denis O'Hare as Financial News Analyst

Charlie Hewson as Brian the Orderly

Court Young as Officer Doherty

Poorna Jagannathan as Dr. Neyer's Nurse

Joshua Rollins as Funeral Minister

Lee Wong as Mr. Waturi

Kae Shimizu as Asian Translator

Brenda Schad as Pregnant Woman

Ross Klavan as Financial News Analyst