Paulette Goddard as Lucretia Borgia

John Lund as Alfonso D'Este

Macdonald Carey as Cesare Borgia

Albert Dekker as Vanetti

John Sutton as Prince Bisceglie

Raymond Burr as Michelotto

Donald Randolph as Tiziano

Charles Dayton as Bastino

Anthony Caruso as Captain of the Guard

Dick Foote as Negligent Sentry

William Farnum as Conti Peruzzi

Kate Drain Lawson as Gemma

Nicholas Joy as Chamberlain

Fritz Leiber as Filippo

Rose Hobart as Lady Eleanora

Douglas Spencer as False Physician

Nestor Paiva as Mayor

Frank Puglia as Bolfi

Houseley Stevenson as Councillor

Robert Greig as Councillor

Don Beddoe as Councillor

Ian Wolfe as Councillor (uncredited)