Demi Lovato as Smurfette (voice)

Rainn Wilson as Gargamel (voice)

Joe Manganiello as Hefty (voice)

Jack McBrayer as Clumsy (voice)

Danny Pudi as Brainy (voice)

Mandy Patinkin as Papa Smurf (voice)

Julia Roberts as Smurfwillow (voice)

Michelle Rodriguez as Smurfstorm (voice)

Ellie Kemper as Smurfblossom (voice)

Ariel Winter as Smurflily (voice)

Meghan Trainor as SmurfMelody (voice)

Jake Johnson as Grouchy (voice)

Dee Bradley Baker as Monty (voice)

Frank Welker as Azrael (voice)

Bret Marnell as Snappy Bug / Handy Smurf (voice)

Brandon Jeffords as Cauldron (voice)

Kelly Asbury as Nosey Smurf (voice)

Gabriel Iglesias as Jokey (voice)

Tituss Burgess as Vanity (voice)

Jeff Dunham as Farmer (voice)

Patrick Ballin as Patient Smurf / Frank the Caterpillar (voice)

Gordon Ramsay as Baker (voice)

Melissa Sturm as SmurfJade (voice)

Alan Mechem as Passerby Smurf (voice)

Danik Thomas as Karate Smurf (voice)

Eric Bauza as Additional Voices (voice)

Ashley Bell as Additional Voices (voice)

Bob Bergen as Additional Voices (voice)

Debi Derryberry as Additional Voices (voice)

Terri Douglas as Additional Voices (voice)

Jeff Fischer as Additional Voices (voice)

Jennifer Crystal Foley as Additional Voices (voice)

Jackie Gonneau as Additional Voices (voice)

Josh Keaton as Additional Voices (voice)

Marcella Lentz-Pope as Additional Voices (voice)

Yuri Lowenthal as Additional Voices (voice)

Scott Menville as Additional Voices (voice)

Max Mittelman as Additional Voices (voice)

Courtney Peldon as Additional Voices (voice)

Ashleigh Prather as Additional Voices (voice)

Lashana Rodriguez as Additional Voices (voice)

Anne Sackmann as Additional Voices (voice)

Tara Strong as Additional Voices (voice)

Brittanny Tuerpe as Additional Voices (voice)

Kari Wahlgren as Additional Voices (voice)

Lisa Wilhoit as Additional Voices (voice)

Matthew Wood as Additional Voices (voice)

Shelby Young as Additional Voices (voice)