Alec Baldwin as Theodore Templeton (voice)

Steve Buscemi as Francis E. Francis (voice)

Miles Bakshi as Tim Templeton (voice)

Jimmy Kimmel as Ted Templeton (voice)

Lisa Kudrow as Janice Templeton (voice)

Tobey Maguire as Narrator / Older Tim Templeton (voice)

Conrad Vernon as Eugene Francis (voice)

James McGrath as Wizzie / Elvis Impersonator (voice)

David Soren as Jimbo (voice)

Nina Zoe Bakshi as Tim's Daughter / Girl / Little Girl (voice)

Tom McGrath as TV Chef (voice)

Walt Dohrn as Photographer (voice)

James Ryan as Story Bear (voice)

Eric Bell Jr. as Triplets (voice)

ViviAnn Yee as Staci (voice)

Edie Mirman as Big Boss Baby (voice)

James Izzo as Elvis impersonator (voice)

Chris Miller as Captain Ross (voice)

Chloe Albrecht as Hazmat Baby (voice)

Andrea Montana Knoll as Flight Attendant (voice)

Joseph Izzo as Elvis Impersonators (voice)

Glenn Harmon as Airport Announcer (voice)

Brian Hopkins as Airport Security Guard (voice)

Jules Winter as Crying Boy / Little Boy / Boy (voice)