Frances McDormand as Jane

Christian Bale as Sam

Kate Beckinsale as Alex

Natascha McElhone as Sara

Alessandro Nivola as Ian McKnight

Lou Barlow as Fripp

Russell Pollard as Rowan

Imaad Wasif as Dean

Mickey Petralia as Mickey

Melissa De Sousa as Claudia

Alexandra Carter as Darla

Michelle DeMirjian as China

Rick Gonzalez as Wyatt

Dennis Howard as Mr. Elliott

Catherine McGoohan as Mrs. Elliott

Judith Montgomery as Woman 1

Patricia Place as Woman 2

Willo Hausman as Cambridge party guest #1

Greg Wolfson as Cambridge party guest #2

Brandy Nightingale as Cambridge party guest #3

Catharine Scott as Stewardess

Marcus Ashley as Tom

Lyle Kanouse as Hospital patient #1

Marcia Cholodenko as Hospital patient #2

Gina Doctor as Gloria

Lauri Johnson as Landlord

Tom Griffiths as Manager

Reef Karim as ER doctor

Lou Cutell as Elderly Man

Zeus as Elderly man’s dog

Nick Kiriazis as Justin

Heidi Sulzman as Laura

Ariel Felix as Mark

Marie Blanco as Debby

Ted Koland as Room service guy

Philip Pavel as Concierge

Mark Rogerson as Doctor

Justin Meldal-Johnsen as Soft rocker

Mark Linkous as Himself

Daniel Lanois as Himself