Jennifer Aniston as Rose O'Reilly

Jason Sudeikis as David Clark

Emma Roberts as Casey Mathis

Will Poulter as Kenny Rossmore

Ed Helms as Brad Gurdlinger

Nick Offerman as Don Fitzgerald

Kathryn Hahn as Edie Fitzgerald

Molly C. Quinn as Melissa Fitzgerald

Tomer Sisley as Pablo Chacon

Matthew Willig as One-Eye

Luis Guzmán as Mexican Cop

Thomas Lennon as Rick Nathanson

Mark L. Young as Scottie P.

Ken Marino as Todd - Strip Club Owner

Laura-Leigh as Kymberly

Crystal Nichol as Brad's Receptionist

D.A. Obahor as Parking Cop

Brett Gentile as White Bread Dad

Kelly Collins Lintz as White Bread Mom

Sam Richardson as TSA Agent

Lynn Talley as Stylist

Alan Gilmer as Middle Aged Man

Denielle Fisher Johnson as Flight Attendant #1

Deborah Chavez as Flight Attendant #2

Kevin Dorff as Border Guard #1

Rawson Marshall Thurber as The Ultimate Border Guard

Kurt Grossi as Border Guard #3

Dave McElhaney as White Gringo

Brendan Hunt as Sketchy Dude

Scott Adsit as Doctor

Vickie Eng as Hospital Nurse

Lunden De'Leon as Hospital Receptionist

Joey Nappo as Gutter Punk #1

Joshua Mikel as Gutter Punk #2

Matt Schweppe as Gutter Punk #3

Tonya Bludsworth as Soccer Mom

Matthew Cornwell as Dan Johnson

Marcus Viscidi as Business Man

Loren Anthony as Mexican Border Crosser (uncredited)

Joshua R. Aragon as Drug Cartel Member (uncredited)

Lionel Archuleta as Mexican Pedestrian (uncredited)

Jenique Bennett as Stripper (uncredited)

Ashley Blankenship as Hot Tub Bikini Girlfriend (uncredited)

Robert Crayton as Kidnapper (uncredited)

Lindsay Davis as Hot Tub Girlfriend (uncredited)

Tait Fletcher as Creepy Trucker (uncredited)

William Frasca as Pedestrian (uncredited)

Amanda Fresquez as Airplane Passenger (uncredited)

Lawrence Gilligan as Border Guard (uncredited)

Saeri Lee as Pedestrian (uncredited)

Natalia Marie as Stripper (uncredited)

Brian Patrick Moize as Strip Club Bouncer (uncredited)

Patrick V. Murphy as Mexican Taxi Driver (uncredited)

Ed Ricker as Fair Goer (uncredited)

John Henry Scott as Stilt Walker (uncredited)

Nathan Marcus Smith as Coffee Shop Patron (uncredited)

Michael E. Stogner as Airline Passenger (uncredited)

Shane Thompson as Strip Club Patron (uncredited)