Tim Curry as Yegor (voice)

Robert Patrick as Louie (voice)

Kelly Ripa as Nat's Mom (voice)

Trevor Gagnon as Nat (voice)

Philip Bolden as I.Q. (voice)

Nicollette Sheridan as Nadia (voice)

Ed Begley Jr. as Poopchev (voice)

David Gore as Scooter (voice)

Christopher Lloyd as Amos (voice)

Adrienne Barbeau as Scooters Mom (voice)

Buzz Aldrin as Himself

Eddie Frierson as Commander Aldrin

David Cowgill as Commander Collins

Steven Kramer as Leonide

Sophie Simpson as Katie (voice)

Sandy Simpson as Commander Armstrong (voice)

Phil Proctor as Senior Official (voice)

Lloyd Sherr as Mission Control 1969 (voice)

Nicholas Guest as Fly Buddy #1 (voice)

Archie Hahn as Fly Buddy #2

Lynnanne Zager as Fly at Launch (voice)

Scott Menville as Butch (voice)

Michael McConnohie as American Newscaster (voice)

Doug Stone as Russian Newscaster (voice)

Jessica Gee-George as Maggot #1 (voice)

Mona Marshall as Maggot #2 (voice)

Barbara Goodson as Maggot #3 (voice)

Gregg Berger as Pale Russian Fly (voice)

Grant George as Pale Russian Fly (voice)

Dean Wein as Additional Voices (voice)

Melora Harte as Additional Voices (voice)

Max Burkholder as Mom's Maggot (voice)