Dwayne Johnson as Jack Bruno

AnnaSophia Robb as Sara

Alexander Ludwig as Seth

Carla Gugino as Dr. Alex Friedman

Ciarán Hinds as Burke

Tom Everett Scott as Matheson

Christopher Rodriguez Marquette as Pope

Billy Brown as Carson

Garry Marshall as Dr. Donald Harlan

Kim Richards as Tina

Ike Eisenmann as Sheriff Antony

Tom Woodruff Jr. as Siphon

John Duff as Frank

Bob Koherr as Marty

Kevin Christy as Matt

Bob Clendenin as Lloyd

Sam Wolfson as Imperial Stormtrooper Ciardi

Bryan Fogel as Imperial Stormtrooper Gray

Robert Torti as Dominick

John Kassir as Chuck

Beth Kennedy as Stenftenagel

Jonathan Slavin as Gallagher

Harry S. Murphy as Analyst D. Pleasence

Ted Hartley as Four-Star General V. Lewton

Thomas Conroy as General E. Albert

Meredith Salenger as Natalie Gann

Andrew Shaifer as Casey Taylor

Suzanne Krull as Gail Ross

Steve Rosenbaum as Oren Bergman

Christine Lakin as Sunday

Corri English as Herself (Brokedown Cadillac)

Randy Dunham as Himself (Brokedown Cadillac)

Don Ian as Himself (Brokedown Cadillac)

Jeff LeGore as Himself (Brokedown Cadillac)

Danny Reuland as Himself (Brokedown Cadillac)

Dave Engfer as Iscovich

Omar J. Dorsey as Police Officer Hough

Joseph Leo Bwarie as Frankie Valet

Paul Nygro as Teddy Tentacles

Brandon Scott Miller as Hendricks

Andrew T. Janey as Repola

Dennis Hayden as Ray

Huang Shengyi as Shira the UFO Huntress

Hiromi Oshima as Fem-Alien #1

Christina Wun as Fem-Alien #2

Christopher Dobler as Hansen

Garrett Patrick Marshall as Bomback

Buck as Junkyard

Cheech Marin as Eddie

Jeff Corbin as Black Ops Soldier (uncredited)

Pleasant Wayne as Bar Girl