David Duchovny as Tom

Julianne Moore as Rebecca

Billy Crudup as Tobey

Maggie Gyllenhaal as Elaine

Justin Bartha as Jasper Bernard

Eva Mendes as Faith Faison

Ellen Barkin as Norah

Garry Shandling as Dr. Beekman

Sterling K. Brown as Rand

Liam Broggy as David

Dagmara Dominczyk as Pamela

Jim Gaffigan as Gordon

James Le Gros as Dante

Gretchen Cleevely as Assistant Stage Manager

David Greenspan as Francis, the Director

Bob Balaban as Tobey's Therapist

Cal Freundlich as Cosmos