Antonio Banderas as El Mariachi

Johnny Depp as CIA Agent Jeffrey Sands

Cheech Marin as Belini

Salma Hayek Pinault as Carolina

Mickey Rourke as Billy Chambers

Willem Dafoe as Armando Barillo

Eva Mendes as CIA Agent Ajedrez

Danny Trejo as Cucuy

Rubén Blades as Jorge, Retired FBI Agent

Enrique Iglesias as Lorenzo

Marco Leonardi as Fideo

Troy Robinson as Romero

Gerardo Vigil as General Marquez

Pedro Armendáriz Jr. as President of Mexico

Julio Oscar Mechoso as Nicholas, Presidential Advisor

Tito Larriva as Cab Driver

Miguel Couturier as Dr. Guevera

Tony Valdes as Chicle Boy

José Luis Avendaño as Alvaro

Rodolfo De Alexandre as Omar

Natália Torres as El Mariachi's Daughter

Steve Constancio as Right Hand

Ermahn Ospina as Qui-Que

Luz María Rojas as Pistolera

Mario Simon as Cook

Bernard Hacker as Blascoe

Cecilia Tijerina as Waitress

Carola Vázquez as Hospital Administrator

René Gatica as Chief Federale

Silvia Santoyo as Bachelorette

Juan Pablo Llaguno as Bull Fighter

Ignacio Torre as Teacher

Rojo Grau as Manny

Jorge Becerril as Taco

Víctor Carpinteiro as Left Nut

Dagoberto Gama as Que Pasa

Thomas Rosales Jr. as Bartender with Gun (uncredited)

Khristian Lupo as Soldier (uncredited)