Johnny Depp as Fred Abberline

Heather Graham as Mary Kelly

Ian Holm as Sir William Gull

Robbie Coltrane as Peter Godley

Ian Richardson as Sir Charles Warren

Jason Flemyng as Netley

Katrin Cartlidge as Dark Annie Chapman

Terence Harvey as Ben Kidney

Susan Lynch as Liz Stride

Paul Rhys as Dr. Ferral

Lesley Sharp as Kate Eddowes

Estelle Skornik as Ada

Nicholas McGaughey as Officer Bolt

Annabelle Apsion as Polly

Joanna Page as Ann Crook

Mark Dexter as Albert Sickert / Prince Edward Albert Victor

Danny Midwinter as Constable Withers

Samantha Spiro as Martha Tabram

David Schofield as McQueen

Bryon Fear as Robert Best

Peter Eyre as Lord Hallsham

Cliff Parisi as Mac Bartender

Sophia Myles as Victoria Abberline

Ralph Ineson as Gordie

Amy Huck as Gull's Maid

Rupert Farley as Doss Landlord

Donald Douglas as Hospital Director

John Owens as Marylebone Governor

Liz Moscrop as Queen Victoria

Ian McNeice as Robert Drudge

Steve John Shepherd as Special Branch Constable

Al Hunter Ashton as Stonecutter

Poppy Rogers as Alice Crook

Bruce Byron as Ann Crook's Father

Melanie Hill as Ann Crook's Mother

Andy Linden as Carpenter

David Fisher as Carpenter / Letter Writer

Gary Powell as Constable #1

Steve Chaplin as Constable #2

Vincent Franklin as George Lusk

Louise Atkins as Bold Hooker

Anthony Parker as John Merrick

James Greene as Masonic Governor

Dominic Cooper as Constable #3

Carey Thring as Police Photographer

Vladimír Kulhavý as Rag & Bone Man

Graham Kent as Records Clerk

Rupert Holliday-Evans as Sailor

Simon Harrison as Thomas Bond

Paul Moody as Young Doctor

Glen Berry as Young Labourer

Charles Parish as Labourer #2

Gerry Grenn as Funeral Minister / Letter Writer