Teresa Wright as Ruth Simmons

Louis Hayward as Morey Bernstein

Nancy Gates as Hazel Bernstein

Kenneth Tobey as Rex Simmons

Richard Anderson as Dr. Deering

Tom McKee as Catlett

Janet Riley as Lois Morgan

Charles Boaz as Jerry Thomas

Lawrence Fletcher as Cranmer

Charles Maxwell as Father Bernard

Walter Kingsford as Professor

Noel Leslie as Edgar Cayce

William Joseph Barker as Self

Eilene Janssen as Bridey Murphy Age 15

Bradford Jackson as Brian MacCarthy Age 17

James Kirkwood as Brian MacCarthy Age 68

Hallene Hill as Bridey Murphy Age 66

Denise Freeborn as Bridey Murphy Age 8

Ruthie Robinson as Bridey Murphy Age 4

James Bell as Hugh Lynn Cayce

Jan Bradley as Guest (Uncredited)

Alexander Campbell as Dr. May (Uncredited)

Hugh Corcoran as Duncan Murphy Jr. Age 10

Anne Cornwall as Mother (Uncredited)

Tom Dillon as John MacCarthy (Uncredited)

Flora Jean Engstrom as Hysterical Woman (Uncredited)

Franklyn Farnum as Druggist (Uncredited)

Charles Fogel as Druggist (Uncredited)

Marion Gray as Mrs. Fuller (Uncredited)

David Halper as Butch (Uncredited)

Stuart Holmes as Guest (Uncredited)

Sharon Manns as Crippled Girl (Uncredited)

Ken Miller as Duncan Murphy Jr. Age 17-19

Tom Nolan as Crippled Boy (Uncredited)

James O'Rear as Reverend Conway (Uncredited)

Mike Riva as Druggist (Uncredited)

Earle Ross as Morey Bernstein's Father (Uncredited)

Dick Ryan as Duncan Murphy Sr. / Duncan Murphy Jr. at Age 70 (Uncredited)

Josephine Whittell as Mrs. Shayne (Uncredited)

Wendy Winkelman as Rex's Daughter (Uncredited)

Jeane Wood as Kathleen Murphy (Uncredited)