Brandon Routh as Clark Kent / Superman

Kate Bosworth as Lois Lane

Kevin Spacey as Lex Luthor

James Marsden as Richard White

Parker Posey as Kitty Kowalski

Frank Langella as Perry White

Sam Huntington as Jimmy Olsen

Eva Marie Saint as Martha Kent

Marlon Brando as Jor-El

Kal Penn as Stanford

Tristan Lake Leabu as Jason White

David Fabrizio as Brutus

Ian Roberts as Riley

Vincent Stone as Grant

Jack Larson as Bo the Bartender

Noel Neill as Gertrude Vanderworth

Keegan Joyce as Boy with Camera

Jordana Beatty as Little Girl

Rob Flanagan as Bank Gunner

Stephan Bender as 15 Year Old Clark

Peta Wilson as Bobbie-Faye

Jeff Truman as Gil

Barbara Angell as Polly

Ian Bliss as Shuttle Commander

Ansuya Nathan as Shuttle Pilot

Richard Branson as Shuttle Engineer

Warwick Young as 777 Co-Pilot

Bradd Buckley as 777 Navigator

Bill Young as Mission Control Flight Director

Karina Bracken as Hospital Ward Nurse

Raelee Hill as Hospital Nurse

Frederique Fouche as French News Anchor

Rebecca Barratt as German Reporter

Karen Pang as Hospital Reporter #8

Jennifer Sciole as EMT (uncredited)

Donald MacDonald as British Scientist

James Karen as Ben Hubbard

Robert Meyer Burnett as Cape Canaveral Reporter