James Denton as Superman / Clark Kent (voice)

Christina Hendricks as Lois Lane (voice)

Anthony LaPaglia as Lex Luthor (voice)

Ed Asner as Perry White (voice)

Linda Cardellini as Nasthalthia Luthor (voice)

Matthew Gray Gubler as Jimmy Olsen (voice)

Arnold Vosloo as Bar-El (voice)

Frances Conroy as Martha Kent (voice)

John DiMaggio as Samson / Ultra-Sphinx (voice)

Alexis Denisof as Dr. Leo Quintum (voice)

Chris Cox as Lead Agent (voice)

Steve Blum as Atlas / General Sam Lane / Astronaut #1 (voice)

Obba Babatundé as Judge / Bibliobot (voice)

Robin Atkin Downes as Solaris (voice)

Michael Gough as Parasite (voice)

Finola Hughes as Lilo (voice)

Kevin Michael Richardson as Steve Lombard / Lizard Man / Convict (voice)

Fred Tatasciore as Krull / Robots / Astronaut #2 (voice)

Cathy Cavadini as Floral / Cat Grant (voice)