Spencer Tracy as John J. Macreedy

Robert Ryan as Reno Smith

Walter Brennan as Doc T.R. Velie Jr.

Lee Marvin as Hector David

Dean Jagger as Tim Horn

Anne Francis as Liz Wirth

John Ericson as Pete Wirth

Ernest Borgnine as Coley Trimble

Russell Collins as Mr. Hastings

Walter Sande as Sam

Billy Dix as Cafe Lounger (uncredited)

K.L. Smith as Cafe Lounger (uncredited)

Robert Griffin as Second Train Conductor (uncredited)

Harry Harvey as First Train Conductor (uncredited)

Bobby Johnson as One of Two Porters (uncredited)

Francis McDonald as Tall - White-haired Cafe Lounger (uncredited)