Henry Fonda as Manny Balestrero

Vera Miles as Rose Balestrero

Anthony Quayle as Frank D. O'Connor

Harold J. Stone as Detective Lt. Bowers

Charles Cooper as Detective Matthews

John Heldabrand as Tomasini

Esther Minciotti as Mama Balestrero

Doreen Lang as Ann James

Laurinda Barrett as Constance Willis

Norma Connolly as Betty Todd

Nehemiah Persoff as Gene Conforti

Lola D'Annunzio as Olga Conforti

Kippy Campbell as Robert Balestrero

Robert Essen as Gregory Balestrero

Richard Robbins as Daniel

Dayton Lummis as Judge Groat

Peggy Webber as Miss Dennerly

Alfred Hitchcock as Prologue Narrator (voice) (uncredited)

Charles Aidman as Jail Medical Attendant (uncredited)

Mary Boylan as Curious Deli Customer (uncredited)

Bonnie Franklin as Young Girl (uncredited)

Bernard Herrmann as Stork Club Piano Player (uncredited)

Werner Klemperer as Dr. Bannay (uncredited)

Patricia Morrow as Young Girl (uncredited)

Harry Dean Stanton as Department of Corrections Employee (uncredited)

Tuesday Weld as Giggly Girl (uncredited)

Maurice Wells as Department of Corrections Employee (uncredited)

Henry Beckman as Prisoner at Arraignment Hearing (uncredited)

Paul Bryar as Interrogation Officer (uncredited)

David Kelly as Policeman (uncredited)

Donald May as Arresting Patrolman (uncredited)

Frances Reid as Mrs. O'Connor (voice) (uncredited)

Penny Santon as Spanish Woman (uncredited)

Clarence Straight as Policeman (uncredited)

Emerson Treacy as Mr. Wendon - Insurance Manager (uncredited)

John Vivyan as Det. Holman (uncredited)

Ray Bennett as Policeman (uncredited)

Dee Carroll as Small Role (uncredited)