Chiranjeevi as Shankar Prasad / Shankar Dada

Srikanth as ATM

Sonali Bendre as Dr. Sunitha "Chitti"

Paresh Rawal as Dr. J. Rama Lingeshwara Rao

Girish Karnad as Satya Prasad

Vennira Aadai Nirmala as Shankar Prasad's mother

M. S. Narayana as Dr. Chidambaram MBBS, FRCS

Surya Bhagawan Das as Dr. Mohammed Rafi

Deepti Nallamothu as Meena

Sharwanand as Vijay

Panja Vaisshnav Tej as Cameo Appearance as Child Artist

Ali Basha as Thief

Ahuti Prasad as Corrupted Doctor

Gauahar Khan as Special appearance in song

Venu Madhav as Malhotra, Shankar's henchmen

Tirupati Prakash as

Chalapathi Rao as

Bhupinder Singh as Pandu Dada

Banerjee as Corrupted Faculty

Narsing Yadav as Shankar's henchmen

Thotapalli Madhu as

Athili Lakshmi as

Duvvasi Mohan as

Karate Kalyani Padala as

Anjala Zaveri as Cameo Appearance in “Chaila Chaila” song

Gauahar Khan as Special appearance in the song "Naa Pera Kanchan Mala"

Pawan Kalyan as Special appearance in song