Millie Bobby Brown as Enola Holmes

Henry Cavill as Sherlock Holmes

Sam Claflin as Mycroft Holmes

Helena Bonham Carter as Eudoria Holmes

Louis Partridge as Lord Tewkesbury

Adeel Akhtar as Lestrade

Fiona Shaw as Miss Harrison

Frances de la Tour as The Dowager

Burn Gorman as Linthorn

Susan Wokoma as Edith

Claire Rushbrook as Mrs. Lane

David Bamber as Sir Whimbrel

Hattie Morahan as Lady Tewkesbury

Gaby French as Seamstress

Paul Copley as Station Master

Ellie Haddington as Miss Gregory

Alex Kelly as Miss Gregory II

James Duke as Footman

Connor Catchpole as Gardener

Sarah Flind as Tea Shop Assistant

Dempsey Bovell as Fleet Street Hawker

Neil Bell as Constable

Sofia Stavrinou as Young Enola

Sophie Dixon as Toddler Enola

David Kirkbride as Agitator

Delroy Atkinson as Porter

Mary Roscoe as Grace Whitting

Anthony Aje as Newspaper Boy (House of Lords)

Anthony Rickman as Newspaper Boy (Fleet Street)

Philip Scott-Wallace as Newspaper Editor

Tuyen Do as Boarding School Teacher

Esther Coles as Miss Fox

Owen Atlas as Young Sherlock Holmes (uncredited)

Paul Parker as Police Inspector (uncredited)

Heather Pearse as Hawker (uncredited)

Jay Simpson as Conductor (uncredited)