Danny DeVito as Frank Menure

Kathy Bates as Agnes Menure

Ron Livingston as Dr. Richard Clayton

Neve Campbell as Ellen Minnola

Beverly D'Angelo as Angela Minnola

Bob Odenkirk as Mitch Clayton

Edward Herrmann as Doug Clayton

Christine Baranski as Arleen Clayton

Martin Mull as Jeffry Morton

Michael McKean as Ken Hyman

M.C. Gainey as Spicer

Star Jones as Holly Davis

Ed Begley Jr. as Mr. Manoire

Debbi Morgan as Mrs. Manoire

Pete Schwaba as Meat Delivery Man

Jimmy Pardo as Angry Driver

Dierdre Holder as Carol

Rose Abdoo as Frustrated Housewife

Terry Cooley as Prison Inmate

Connie Sawyer as Old Lady

Tracey Walter as Toupee Salesman

Sam Rubin as TV Anchorman

Dave Bautista as Wrestler (uncredited)

Jordan Brower as Prisoner (uncredited)

Jon Donahue as Additional voices (uncredited)

Paul Lévesque as Wrestler (uncredited)

Emo Philips as Guest at Carnival Party (uncredited)