Sam Lucas as Uncle Tom

Irving Cummings as George Harris

Walter Hitchcock as George Shelby

Hattie Delaro as Mrs. Shelby

Master Abernathy as George Shelby Jr. as a boy

Teresa Michelena as Eliza

Paul Scardon as Haley

Marie Eline as Evangeline 'Little Eva' St. Clair

Garfield Thompson as St. Clair

Roy Applegate as Simon Legree

Boots Wall as Topsy