Jake T. Austin as Yankee Irving (voice)

Rob Reiner as Screwie (voice)

William H. Macy as Lefty Maginnis (voice)

Mandy Patinkin as Stanley Irving (voice)

Richard Kind as Hobo Andy / Maitre D' (voice)

Robert Wagner as Mr. Robinson (voice)

Raven-Symoné as Marti Brewster (voice)

Whoopi Goldberg as Darlin' (voice)

Brian Dennehy as Babe Ruth (voice)

Ritchie Allen as Officer Bryant (voice)

Cherise Boothe as Rosetta Brewster (voice)

Ralph Coppola as Sandlot Kid #2 (voice)

Jesse Bronstein as Sandlot Kid #1 (voice)

Jason Harris as Announcer (voice)

Ed Helms as Hobo Louie (voice)

Ray Iannicelli as Conductors / Umpire (voice)

Gideon Jacobs as Bully Kid Tubby (voice)

Marcus Maurice as Willie (voice)

Amanda Parsons as Emily Irving (voice)

Dana Reeve as Emily Irving (voice)

Will Reeve as Big Kid (voice)

Ron Tippe as Hobo Jack (voice)

Joe Torre as Yankees' Manager (voice)

Forest Whitaker as Lonnie Brewster (voice)

Conor J. White as Bully Kid Arnold (voice)

Rochelle Hogue as Additional Voices (voice)

Sondra James as Additional Voices (voice)

Greta Martin as Additional Voices (voice)

Christie Moreau as Additional Voices (voice)

Sean Oliver as Additional Voices (voice)

Charles Parnell as Additional Voices (voice)

Dennis T. Carnegie as Additional Voices (voice)

Jim Titus as Additional Voices (voice)

Cornell Womack as Additional Voices (voice)

Robin Williams as Napoleon Cross (uncredited)