William H. Macy as Lefty Maginnis (voice)

Rob Reiner as Screwie (voice)

Brian Dennehy as Babe Ruth (voice)

Ritchie Allen as Officer Bryant (voice)

Jake T. Austin as Yankee Irving (voice)

Cherise Boothe as Rosetta Brewster (voice)

Jesse Bronstein as Sandlot Kid #1 (voice)

Ralph Coppola as Sandlot Kid #2 (voice)

Whoopi Goldberg as Darlin' (voice)

Jason Harris as Announcer (voice)

Ed Helms as Hobo Louie (voice)

Ray Iannicelli as Conductors / Umpire (voice)

Gideon Jacobs as Bully Kid Tubby (voice)

Richard Kind as Hobo Andy / Maitre D' (voice)

Marcus Maurice as Willie (voice)

Amanda Parsons as Emily Irving (voice)

Mandy Patinkin as Stanley Irving (voice)

Will Reeve as Big Kid (voice)

Raven-Symoné as Marti Brewster (voice)

Ron Tippe as Hobo Jack (voice)

Joe Torre as Yankees' Manager (voice)

Robert Wagner as Mr. Robinson (voice)

Forest Whitaker as Lonnie Brewster (voice)

Conor J. White as Bully Kid Arnold (voice)

Rochelle Hogue as Additional Voices (voice)

Sondra James as Additional Voices (voice)

Greta Martin as Additional Voices (voice)

Christie Moreau as Additional Voices (voice)

Sean Oliver as Additional Voices (voice)

Charles Parnell as Additional Voices (voice)

Dennis T. Carnegie as Additional Voices (voice)

Jim Titus as Additional Voices (voice)

Cornell Womack as Additional Voices (voice)

Dana Reeve as Emily Irving (voice)

Robin Williams as Napoleon Cross (uncredited)