Matthew McConaughey as Ron Woodroof

Jennifer Garner as Eve

Jared Leto as Rayon

Denis O'Hare as Dr. Sevard

Steve Zahn as Tucker

Michael O'Neill as Richard Barkley

Dallas Roberts as David Wayne

Griffin Dunne as Dr. Vass

Kevin Rankin as T.J.

Donna DuPlantier as Nurse Frazin

Deneen Tyler as Denise

J.D. Evermore as Clint

Ian Casselberry as Hispanic Orderly

Noelle Wilcox as Kelly

Bradford Cox as Sunny

Rick Espaillat as Michael

Lawrence Turner as Foreman

Lucius Falick as Freddie

James DuMont as Rayon's Father

Jane McNeill as Francine Suskind

Don Brady as Tucker's Father

Matthew Thompson as Effeminate Man

Tony Bentley as Judge

Sean Boyd as Border Agent

Rachel Wulff as News Anchor

Neeona Neal as Stripper

Scott Takeda as Mr. Yamata

Jonathan Tabler as Rick Ferris

Joji Yoshida as Dr. Hiroshi

Carl Palmer as FDA Customs Agent

Martin Covert as Ian

Douglas M. Griffin as Rog

David Lichtenstein as Cop

Craig Borten as Quicksilver Cowboy

Henry Frost as Gay Cowboy

Arthur Smith as Rodeo Announcer

Adam Dunn as Neddie Jay (uncredited)

Juliet Reeves London as Rodeo Girl (uncredited)

Jeanine Hill as Rodeo Girl (uncredited)

Sarah Eilts as Ron's Hooker (uncredited)

Lily Virginia Filson as Dancer (uncredited)

Steffie Grote as The Girl With The Snake Tattoo (uncredited)