James Franco as Darl Bundren

Danny McBride as Vernon Tull

Logan Marshall-Green as Jewel

Ahna O'Reilly as Dewey Dell

Jim Parrack as Cash

Tim Blake Nelson as Anse

Beth Grant as Addie Bundren

Jennifer Kristen Howell as Cora Tull

Brady Permenter as Vardaman Bundren

Natalie Minton as Kate Tull

Jessica Lemon Wilkinson as Mrs. Armstid

Kenny Cook as Grummet

Brian Lally as Dr. Peabody

Anna Kooris as Eula Tull

Vince Jolivette as Young Whitfield

Scott Haze as Skeet McGowan

Coby Batty as Gillespie

John Still as Samson

Jesse Heiman as Jody