Nicole Kidman as Isabel Bigelow

Will Ferrell as Jack Wyatt

Shirley MacLaine as Iris Smythson / Endora

Michael Caine as Nigel Bigelow

Jason Schwartzman as Ritchie

Kristin Chenoweth as Maria Kelly

Heather Burns as Nina

Jim Turner as Larry

Stephen Colbert as Stu Robison

David Alan Grier as Jim Fields

Michael Badalucco as Joey Props

Carole Shelley as Aunt Clara

Steve Carell as Uncle Arthur

Katie Finneran as Sheila Wyatt

James Lipton as Himself

Conan O'Brien as Conan O'Brien

Amy Sedaris as Gladys Kravitz

Richard Kind as Abner Kravitz

Ken Hudson Campbell as Writer

P.J. Byrne as Writer

Carole Androsky as Realtor

Annie Mumolo as Bed, Bath and Beyond Shopper

Andrew Friedman as Bed, Bath and Beyond Shopper

Clay Bravo as Coffee Shop Waitress

Heather Maristella as Beverly Hills Hotel Hostess

Jonathan T. Floyd as Cable Man

Ed McMahon as Ed McMahon

Alison MacInnis as Auditioning Actress

Bridget Brno as Auditioning Actress

Dana Daurey as Auditioning Actress

Dorie Barton as Auditioning Actress

Katie Carroll as Auditioning Actress

Jennifer Elise Cox as Auditioning Actress

Laura Sorenson as Auditioning Actress

Brittany Krall as Auditioning Actress

Dawn Ashley Cook as Auditioning Actress

Julia Decker as Auditioning Actress

Jennifer Hall as Book Soup Cafe Waitress

Roxanne Beckford as Francine

Hugh Davidson as Network Executive

Joe Zymblosky as Randall

J.J. Sacha as Voice-Over Announcer

Susan Chuang as Press Conference Reporter

Jordan Black as Press Conference Photographer

Mo Rocca as E! Reporter

Jason George as E! Anchor

Wendi McLendon-Covey as E! Anchor

Julie Claire as Hillary

Terry Savage as Dinner Party Guest

Dianne Dreyer as Production Staff Assistant

Kate Walsh as Sexy Waitress

Valerie Azlynn as Gorgeous Model

Jarrad Paul as Valet

Victor Williams as Police Officer

Liesel Staubitz as Trick-or-Treater

Ruby Rose Skotchdopole as Trick-or-Treater

Molly Gordon as Trick-or-Treater

Nick Lachey as Vietnam Soldier

Abbey DiGregorio as Auditioning Actress

Amelinda Embry as Press Girl (uncredited)

Jessica Mathews as Samatha Lookalike (uncredited)