Sanaa Lathan as Kenya McQueen

Simon Baker as Brian Kelly

Blair Underwood as Mark Harper

Wendy Raquel Robinson as Cheryl

Taraji P. Henson as Nedra

Golden Brooks as Suzette

Mike Epps as Walter

Donald Faison as Nelson McQueen

Alfre Woodard as Joyce McQueen

Earl Billings as Edmund McQueen

Matt Malloy as Edwin

Katharine Towne as Leah Cahan

Stanley DeSantis as Jack Pino

Marcus Brown as Rashid Mohammed

Fuzzy Fantabulous as DJ Fuzzy Fantabulous (voice)

Henry Simmons as Kyle

Russell Hornsby as Dr. Brockton

Tanisha Harper as Stacy

Michelle Griffin as Kiki

Kimberly Barnett as Luna

Rose Rollins as Lauren

K.C. Clyde as Waiter

Lee Garlington as Mrs. Cahan

Tonita Castro as Maria

Gabriel Tigerman as Darren

Rick Fitts as Emcee

John Ratzenberger as Brian's Father (uncredited)