Woody Harrelson as One Eyed Jack Faro

Werner Herzog as The German

Dennis Farina as L.B.J. Deuce Fairbanks

David Cross as Larry Schwartzman

Cheryl Hines as Lainie Schwartzman

Richard Kind as Andy Andrews

Chris Parnell as Harold Melvin

Jason Alexander as Dr. Yakov Achmed

Ray Romano as Fred Marsh

Mike Epps as Reggie Marshall

Judy Greer as Sharon Andrews

Gabe Kaplan as Seth Schwartzman

Michael McKean as Steve Lavisch

Julie Claire as Dr. Jamie Sellers

Barry Corbin as Jimminy 'Lucky' Faro

Shannon Elizabeth as Toni

Estelle Harris as Ruth Melvin

Andrea Savage as Renee Jensen

Andrew Hill Newman as Russell Kalenich - The Dealer

Michael Karnow as Mike Werbe

Robert Thompson as Himself - Tournament Director

Andy Bellin as Poker Pro

Doyle Brunson as Poker Pro

Antonio Esfandiari as Poker Pro

Phil Hellmuth as Poker Pro

Phil Laak as Poker Pro

Daniel Negreanu as Poker Pro

Hank Azaria as Mike "The Bike" Heslov

Tom Hodges as Tim "Tiny Wonders" Woolrich

David Pressman as Melville "Murph Murph" Murphy

Brett Ratner as "Sob Story" Barry Blaustein

Avi Arad as Abdul Shavit

K.D. Aubert as Julie the Waitress

Tommy Lister Jr. as German's Bodyguard

Lance Stockton as German's Bodyguard

Tim Mikulecky as Bitch Slapped Man

Trula M. Marcus as Front Desk Clerk

Cynthia Petrello as Waitress at Vic & Anthony's

Linda Button as Jack's Secretary

Rusty Meyers as Long Island Poker Player

Richard Brodie as Himself

Peter O'Meara as Dave Esme

Tara G. Wise as Lainie's Daughter Ellen

Catherine Rose Young as Lainie's Daughter Catherine

Alec Holden as Little Larry

Hailey McCann as Little Lainie

Orly Shani as Lavisch's Assistant

Naomi Fabe as Lavisch's Assistant

Errol Guidry II as Cajun Larry

Jeff Bowler as Poker Player

Sharon Fann as Dealer at TV Tournament

Marc J. Chaiet as Hotel Guest

Garrett McKechnie as Hotel Guest

Tilman J. Fertitta as Himself

Sean Patrick Flaherty as Sean Marsh

Scotty Gelt as Poker Pro

Bonnie Joy Ashley as Dinner Guest

Harvey Blanc as Bell Desk Captain

Ashley Bowler as Child in Vic and Anthony's

Barry Brandt as Poker Player (uncredited)

Kelly Catey as Lavicsh's Assistant (uncredited)

Randy Charach as Poker Player (uncredited)

John Embry as Poker Player (uncredited)

Steve Grabowsky as Poker Player (uncredited)

Alistair David Herz as Police Officer #1 (uncredited)

Kelly R. Kleinman as Leroy Kelly (uncredited)

Melinda Kramer as Poker Dealer (uncredited)

Riley G. Matthews, Jr. as Poker Player (uncredited)

Dylan Mitro as Lainie's baby (uncredited)

Wesley Okerson as Poker Player (uncredited)

Michael A. Rizza as Poker Player (uncredited)

Brahm Taylor as Rex Copeland (uncredited)

Dave Yekell as Poker Player (uncredited)

Bob Pepper as Poker Player (uncredited)

Phil Gordon as Himself