Luke Goss as Carl 'Luke' Lucas / Frankenstein

Ving Rhames as Weyland

Danny Trejo as Goldberg

Tanit Phoenix as Katrina Banks

Dougray Scott as Niles York

Robin Shou as 14K

Langley Kirkwood as Dr. Klein

Frederick Koehler as Lists

Tanya van Graan as Amber

Sean Cameron Michael as New Doctor

Hlubi Mboya as Satana

Charlbi Dean as Calimity J

Mark Elderkin as Sgt. Fury

Eugene Khumbanyiwa as Nero

Jeremy Crutchley as Psycho

Yrsa Daley-Ward as Salinas

Ebby Weyime as Maria Rodriguez

Kim Suzanne Engelbrecht as Kelly O' Donnell

Roxane Hayward as Prudence

Bart Fouche as Razor

Michelle van Schaik as Olga Braun

Jesselyn Abrahamse as Silky

Roxane Van Rooyen as Elsa

Shaamilla Noordien as Corns

Gina Athans as Ali

Simone Van Rooyen as Alva Twin

Kim Syster as Olivia

Sylvia Mngxekeza as KP Goldberg Fan Guard

Peter Butler as Executive

Natalie Becker as Pretty Reporter

Quentin Chong as Triad Driver

Irina Miccoli as Weyland's Assistant

Chase Armitage as Apache (archive footage)

Dick Ervasti as Commercial voice (uncredited)

Brandon Livanos as Pretty Boy (uncredited)

Anton David Jeftha as The Jackel (uncredited)