Luke Goss as Carl 'Luke' Lucas / Frankenstein

Lauren Cohan as September Jones

Sean Bean as Markus Kane

Danny Trejo as Goldberg

Ving Rhames as Weyland

Tanit Phoenix as Katrina Banks

Robin Shou as 14K

Joe Vaz as Rocco

Frederick Koehler as Lists

Sean Higgs as Hillbilly Con

Patrick Lyster as Warden Medford Parks

Deobia Oparei as Big Bill

Hennie Bosman as Xander Grady

Warrick Grier as Calin

Danny Keogh as Dr. Klein

Tanya van Graan as Holly

Ryan Kruger as Fat Guard

Robyn LeAnn Scott as Big Angry Female Guard

Alex Lorre as Driver

Stephen Jennings as Defense Attorney

Tyrone Keogh as Camerman #2

Trayan Milenov-Troy as Scars

Jenna Saras as Stunning Woman

Chase Armitage as Apache

Michael Solomon as The Sheik

Scott Sparrow as Vinnie

Ricky Botsis as Terry

Michael Dube as Union Blood Member (as Michael T. Dube)

Richard Lothian as Rapist Con

Inge Beckmann as Nurse

Milton Schorr as Prison Bus Guard

Leigh Graves as The D.A

Stephanie Schildknecht as Weyland's Secretary

Lee-Anne Liebenberg as The Sheik’s Navigator Girl

Chelsea King as Big Bill's Navigator Girl

Karlien Seegers as Apache’s Navigator Girl

Dick Ervasti as Commercial voice (uncredited)

Quentin Chong as Triad Assassin

Adam Lazarre-White as Opening Narrator (voice)