Lluís Homar as Rodrigo Borgia

Sergio Peris-Mencheta as César Borgia

María Valverde as Lucrecia Borgia

Paz Vega as Caterina Sforza

Ángela Molina as Vanozza

Katy Louise Saunders as Giulia Farnese

Linda Batista as Sancha de Aragón

Francesca Della Ragione as Domiziana

Eusebio Poncela as Cardenal Giuliano della Rovere

Eloy Azorín as Jofré Borgia

Antonio Valero as Cardenal Ascanio Sforza

David Lowe as Ambassadeur Français

Lucía Jiménez as María Enríquez

Esther Ortega as Isabella

Benedetta Valanzano as Pentesilea

Sergio Múñiz as Juan Borgia

Roberto Enríquez as Paolo Orsini

Antonio Dechent as Michele Corella

Giorgio Marchesi as Alfonso de Aragón

Marco Bocci as Pedro Bembo

Fabio Grossi as Cardenal Rafaele Riario

Antonio Hernández as Cardenal Gianbatista Orsini

Massimo Vanni as Soldier

Diego Martín as Perotto

Enrique Villén as Savanarola

Miguel Ángel Muñoz as Ramón

Javier Tolosa as Gonzalo de Córdoba

Federico Torre as Macellaio

Roberto Álvarez as Burkard

Unax Ugalde as

Julio Mardelo as

Xabier Murua as

Eduardo Torroja as