Sam Rockwell as Samuel

Steve Zahn as Eddie

Mark Ruffalo as Frank

Josh Pais as Mitchell

Paul Giamatti as Veal Chop

Michael Schmidt as Bernie Jr.

Christina Kirk as Hannah

Raymond Serra as Barber

Harvey Fierstein as Good Stuff Leo

Michael Lerner as Big Fat Bernie Gayle

Michael Showalter as Larry

John Hamburg as Philip

Ray Iannicelli as Swoop

Ali Marsh as Sherry

Jacob Reynolds as Cousin Ira

Peter Dinklage as Leflore

Mark Shanahan as Party Coordinator

Emily Doubilet as "Sweet" Denise Schneider

Sidney Zubrow as Pappy

Blue Moreno as M.C. Victor

Ellen Hauptman as Joyce Kaufman

John Tormey as Older Guy

Don Picard as Gunter

Dee Dee Friedman as Barbara

Carl Don as Hyman

Allen Swift as Sol

Seth Herzog as Gold Trophy

Richard Bolster as Gold Trophy

Brian Mullen as Self

Ian Helfer as Janusz

Eric Bogosian as Edward Templeton Sr. (voice)