Hank Azaria as Daniel Collins

Jesse Bradford as Ryan Carmichael

Zooey Deschanel as Kate Collins

Glenne Headly as Samantha

Famke Janssen as Judy Arnolds

Kelly Preston as Lucy Collins

Ray Romano as Skip Collins

Rip Torn as Edmund Collins

Debra Winger as Alice Collins

Piper Laurie as Charlotte Collins

Paget Brewster as Aunt Lily

Brian Posehn as Video Store Clerk

René Auberjonois as Parson Banke

Micole Mercurio as Delilah, Barbara Collins' Neighbor

Lucy Boyle as Girl in Dorm Room

Tania Gunadi as Girl in Dorm Room

Kevin Ruf as Commercial Dad

Michael Panes as Adult Film Director

Michael Chapman as Adult Film Cameraman

Vincent Castellanos as Adult Film Actor

Lisa Maris as Adult Film Actress

Rocco Sisto as District Attorney

Lana Antonova as Lace

Denise Dowse as Judge Welsh

Curtis Garcia as Fred Collins

Keith Garcia as Ted Collins

Mark Harelik as Burt

Matthew Feder as Alice's Silent Son

Allisyn Snyder as Alice's Silent Daughter

Jordan Moen as Alice's Silent Daughter

Natasha Sheridan as Young Kate

Mary Samuels as Hostess at Restaurant

Brandon Waters as Young Ryan at 5

Monica Esswein as Young Kate at 8

Aaron Salazar as Young Ryan at 8

Shaunci Trammel as Young Kate at 11

Ward Stearns Jr. as Young Ryan at 11

Sara Botsford as Mrs. Carmichael

John Lafayette as Doctor Rice

Eric Pierpoint as Mr. Carmichael

Claudette Nevins as Barbara Collins

Emma Chapman as Ryan's Date

Alex Moore as Young Daniel

Sherman Howard as Funeral Director